The synagogue opened in 1871.
On December 13, 1943, the building was seriously damaged and all the interior furnishings were destroyed, with many precious objects, books, and manuscripts burnt in a public book burning.
The synagogue building reopened in 2022 after an extensive restoration that began in 1995.
Sacerdoti, Annie, Guide to Jewish Italy (Brooklyn, NY, 1989);
Yaakov Pinkerfeld, Batei-ha-kneset be-italiya mitkufat ha-renesans 'ad yameinu: perek be-toldot ha-adrikhalut ha-yehudit (Jerusalem, 1954), pp. 47-48;
Bezalel Narkiss, "The Heikhal, Bimah, and Teivah in Sephardi Synagogues," Jewish Art 18 (1992), pp. 30-47.
https://jewish-heritage-europe.eu/2022/10/08/italy-synagogue-in-alessandria/