The synagogue of Novi Sad bears the scars of World War II and the Holocaust. Jews of Novi Sad were imprisoned there before their deportation to Nazi death camps. Afterward, it was used as a storehouse for possessions left behind by the Jews. After the liberation, it was used as a space to distribute humanitarian aid sent from the West.

The synagogue was in use until 1966. With less than 10 percent of its prewar congregation, the community did not have the means to renovate and maintain the temple. Therefore, after years of neglect, it was handed over to the city for management and underwent renovation from 1985 until 1991. The synagogue has been leased to the Novi Sad Municipality since 1991 and has been used as a concert hall and from time to time for the celebration of the Jewish holidays.